An acrylic oven, ribbon burner or heat gun. If you have a cnc router, can mitre the edge and face for very neat and strong join. If no cnc, cut the face out, cut your strips (returns), glue the returns to the face as close as you can get to the edge of the face, but don’t go over and run around with a finishing router set to the depth of the face to get a neat edge. You can use a former to heat and bend the acrylic around to get the proper radius. If you have a cnc, you can make from mdf easily but it all used to be done with hand tools once. This size sign would best to use 6mm for the returns and 4.5 -6mm for the face, but a lot would make it out of 4.5mm face and returns They usually have a 10mm pvc back with the leds mounted and the fixing screws go through the returns into the 10mm pvc. Glue up first with thin glue and then run a heavy thick bead of thick glue Weld-on No.16 all around. It maybe different where you are from but we use 455 opal acrylic for most of these.