I would first ask what the end purpose of your second surface prints would be? Because, let's face it... if you are using a solvent or latex based wide format printer, the print quality for something that could be considered a high end product, isn't that great. It's not actually photographic quality. And acrylic isn't cheap to begin with. So, in terms of dollar per square foot you are going to have to charge a premium in the first place. If you are thinking of something like large menus or restaurant art mounted with stand-offs... then why not just have the prints done on film paper? It's way cheaper, plus it's the best the image can be. And you only have to concern yourself with mounting the print to the acrylic. Also, you can choose to use duratrans, and make them backlit and they carry more density than inkjet.
I'm just sayin'... if the end result is supposed to be high end, then why not actually offer it as a high end product and output it accordingly? Durst Prints can be had as low as 99¢ per sq. ft. And no investment on your part in buying rolls of stuff that would otherwise rarely get used.
Or since these would be primarily used inside you could use a dedicated photo printer like an Epson or Canon. They have a wider color gamut too. Once mounted to acrylic the prints are then sealed like laminated.