This is a loaded question - everyone has their "best" tool in the box.
You need to post up more of what equipment you want to drive and what you are going to produce.
You can break it down into 4 general categories:
1. Design - needed if you are going to build your own files.
2. Receiving software - If you are going to take client's files you need an app that can reliably open and prep them for printing and or plotting.
3. RIP - Needed to drive the printer
4. Cutting program - needed to plot stuff.
So what is best? hard to say.
You can rent Flexisign from SAi by the month and it will do all 4, more or less - I use it, I don't like for 1 & 2 and sometimes 3 (buggy & cranky for no reason).
Illustrator is good at 1 and best at 2 - will not do 3, can do 4 with a plug-in or bridge program (most cutters come with free apps that will do this) Has to be rented monthly for the latest version.
Signlab is another all in one that will do all 4 - I don't use it, but from posts here on the forum it seems (to me) to be a little less capable than Flexi.
Corel Draw - about the same as Illustrator - good at 1, less so dealing with 2 - does not do 3 and can plot via plug-in or bridge program.
Dedicated RIP programs are fairly expensive (and complicated) and work better with some printers over others. Best to figure what printer you are going to purchase before choosing a RIP.
Most printers come with brand limited apps that will print and plot.
I use Flexi 8.6, Flexi 12 (Mutoh version), Illustrator CC (subscription version) CorelDraw X5(my go-to app to build my own layouts) and a bunch of other add-on programs to round things out.
One size does not fit all.
wayne k
guam usa