Yes! I run a HP Scitex FB500 and had their techs tell me that even close to expiration date, there can be issues. And to be honest, the last few batches of fresh ink I've gotten, a tech told me had "subpar performance issues". I manually shake each box at least once a week now. But once it expired, it's replaced. Fortunately our volume hasn't made that too much of an issue, except with white.