Check the type of crop marks you are using, if you use the segmented type with the "T" shaped intermediate mark you can't rotate your layout to cut.
You might be using segmented without out knowing it, if the step size is too large CM won't add the center marks but still label them that way and prevent rotation in CM.
I just ran into this after applying the new updates for CM.
If you want to use segmented crop marks you need to rotate your layout so it is going the way you want it to in the cutter before adding in the crops.
wayne k
guam usa