That's funny to hear this because just last week I was talking t a client about a potential wrap for his horse trailer, and we discussed ideas he would like to see in the wrap design, and I thought we were finished, because typically both sides mirror each other, however he said NO, he wants two different designs on each side of the trailer.
When I explained that you can only see one side at a time, he turned my words against me, and said, exactly, that's why I want them to be different.
So, because THE CUSTOMER is always RIGHT, and is going to pay for the two separate designs, that's what were going to do.
A few years ago I did several 45' goose-neck trailer wrap deigns for some local colleges, and they wanted 4 separate designs one for each side, back and front.
So, although more design work up front, I think it will make a better overall wrap if it's original on each side, IMO.