What do you use to keep your computers secure?
This right here:
Away from the Internet!
I run Windows 98 & XP daily, have done since...well, work it out..All runs as a dedicated and uninterrupted 'unit'
I've said it a lot (much to the annoyance of some users on here) keep production rigs off the internet and don't have internet connected computers have access to production network. Have at least a computer connected to the internet (my business exists mainly with an online connection, not having that, I'm dead, so cutting the cord isn't an option) isolate from the production environment. Scan files that come in and then bring it into the production environment.
It's tedious, especially initially when getting used to everything, but it is about as secure as one can be. The biggest vector of issues (not just malware, but other issues such as updates) happens over the WAN. Like it or not, that's what happens. Doesn't happen to everyone mind you, but that's a risk one takes.
This is a big reason why I don't like SaaS based software. It requires online connection. If one has to have SaaS based software, especially on a Windows machine with their rolling release OS model, that's a risk one takes and just has to make the most of it and minimize your risk.
Running legacy programs on legacy OS especially, no WAN at all to that rig. Running legacy programs on Win 10, no WAN.
If you are using a combination of legacy programs (for whatever reason) and SaaS programs, keep them on separate computers (this is a big thing that will affect workflow and most won't like it, but keep in mind, any Win 10 update (yep, mentioning those updates again) could break your legacy software).
Of course, for me personally, I don't use Windows installed on bare metal on my computers as well. All my production software, I managed to get on a different platform, so that helps. Not everyone can do that, I know (contrary to atleast one user on here thinks), but I do still keep Window VMs around for nostalgia. But even with using a different platform, I still keep production rigs offline. Even though updates (and malware) are less of a concern compared to Windows. At least in my experience.