How to make this sign?

Clear acrylic with full cover digital print on a frosted vinyl, installed with stand offs and caps over the screws.

 

Print onto regular clear and use a matte lam on the back side if you don't have frosted on hand. Set the printer to something like 18 passes so the logo is as opaque as possible.

 

Spot white reverse direct print on a flatbed directly on the material. I've printed many of these.

 

assuming you have a roll to roll HP instead of a flatbed
Also assuming you do not have white ink

print to a frosted material (reverse image), make sure to you use heavy ink coverage(many passes)
install onto the 2nd side (backside) of clear acrylic, this will show the correct orientation when viewed on the front side
mount using standoffs,

would suggest drilling the holes BEFORE applying the vinyl.

 

make sure your drill bits are SHARP.
we have a dedicated set for acrylic,

you are "supposed" to use special bits, but use what works for you.
we like https://www.harborfreight.com/titanium-split-point-drill-bit-set-29-pc-61715.html

NOTE: regardless of the bit you use, MAKE SURE you start with a small bit and increase one size at a time until you have the desired diam.
also, make sure to use tape on the front/back of the acrylic where you are drilling

 

I have a lennox unibit (step bit, cone bit, whatever you call it) that I use exclusively on this stuff. with an 1/8" pilot hole I can turn the unibit by hand and slowly but surely make my hole without sweating the whole time!

 

I use the step bits from Harbor Freight for drilling holes in acrylic. They're cheap and drill perfect holes. Have never drilled a pilot hole first, I just use the step bit.

 

Best way to drill acrylic is with a tile drip (shaped like pointed spade). I can drill a piece of 5mm thick at 10mm from edge with 12mm bit with no risk of cracking. Best discovery I ever made ...