In addition to the skin tones, it will just make gradients in general fade better and more accurately.
For the nature of what most sign shops do, 4 color is more than enough. We have both kinds, 4 and 6 and honestly, unless you are standing 2 feet away, you can't see the problems unless you were really looking for trouble.
If your gradients [which is what skin tones really are].... need to be that dead balls on, we always tell our customers.... you look at signs, you don't smell them. Back up and take in the whole view.
If you're doing photo reproductions and fine arts projects where this quality matters.... you're really looking at the wrong machines altogether. However, like mentioned, by all means, make some files and give them to each vendor blowing smoke up your butt and have them produce them using various profiles on different media. Then make your comparisons with your files, not theirs.