Avery does not recommend primer. Some plastics are lower energy than others, door guards are usually less oily. I usually try to suggest to clients to remove them. Some don't have holes at all, but iirc souls do. In that case stick a 3" strip of reflective horizontally fully across both doors to cover the holes. Reflective is much thicker and won't pop through like cast on holes.
The door guards can always be reinstalled before selling vehicle. Wrapping over is always a maybe and if you primer them they are permanently ruined.