Is there an error code # associated with the 'assertion error'?
Nozzle performance is absolutely key with any and all inkjet printers, large, grand, or small format. One thing that is nice about the HP Latex machines is that nozzle performance is regularly reassessed automatically by the printer, using an Optical Drop Detection routine. One thing that can be very helpful with the Latex 300 Series is that the nozzles that are presently mapped as 'out' are being recorded in the machine's Printer Information document. This document is be dynamically built by going to a browser and punching up the printer's IP Address.
From there, navigate to Support > Service Support > Printer Information > All Pages.
It is important to keep in mind that each printhead in the printer (out of a total of 6) has 2112 nozzles, for a total nozzle count of 12,672 installed in the printer at any time. Some of these nozzles are 'reserve' nozzles which do not get used until a 'primary' nozzle is out, and the reserve nozzle fires in place of the primary, to preserve image quality. These remap assignments are made automatically during periodic Drop Detection routines that occur on a regular and automated basis.
Paul