I turn my Falcon 46" off after I'm done using it. So far we've been using it approximately every other day, and i've never had an issue. Usually I just do a quick nozzle check before i start printing that day, and then a cleaning if it's needed. Haven't had any issues, but found that keeping the wiper blade nice and clean has really helped fix issues with misdirected nozzles and normally I just do one cleaning now.
I just shut it off to lower some of the power draw, since I'm not printing constantly, just a few hours each time I use it.