We don't run the Silk, but I've ran Suede, Mystical (kinda like Silk iirc), Pique, and probably one or two I'm forgetting.
I run them all from the Suede profile, with a little tweaking. Usually just a 12 pass, 120 ink density works for me. You can get rolls with the bad plasticizer effect, however. I've had this problem on rolls of Mystical and rolls of the Dreamscape Matte Vinyl (which we no longer use and have substituted for HP PVC-Free Smooth).
Try wiping the roll with a rag saturated with isopropyl alcohol. If the print clears up, that may be your issue.
Otherwise, good luck. I do believe starting with the Suede profile and going from there is your best bet.