Just finished a job with two aspects:
it was ten sheets of dibond at 1500 x 3050 mm each sheet, profile cut, and also plotted with a plotter-blade to cut the plastic coversheet.
One irregularly-shaped sign used four sheets, horizontally, the corners all meeting in the centre like a + sign, while the other took six big sheets vertically suspended- so it was 9 metres wide by 10 ft high, less the weird router-cut border shape.
Our router could hold the full-sized sheets- it was a matter of having the file set up, and rotated if need be, with the computer-file plate size set as per the sheet size.
The outlines cross off the plate, so I had to cut by line, to trim everything as it ran off where the edge of the sheet would be. Then plot the inner parts, and edge-rout the border.
Then remove that sheet, load the next against a prefixed long & short edge so the origin was always perfect.
The go back to the file on the PC, and use the 'move' command to shift the Y axis by -1500mm (for instance), then trim where the new file's contours go off the plate, then export the plotter blade file, then export the perimeter profile-cut file; then plot, cut, remove the sheet, & put the next one down.
Go back to the software, use the 'move' command to shift the file by -1500mm, trim overlapping contours again, and continue as above.
Hope that makes sense.