Your print quality is impacted by 2 factors - image dpi and printer quality setting. For general sign work that is viewed at more than 5-10 feet away, at the same printer quality setting, you will not find any dramatic improvement above 150 dpi image resolution. If you are doing prints that will be viewed up close, then perhaps 300 dpi is a better choice. In my opinion, 600 dpi is overkill. This is of course assuming you are not magnifying the file in the RIP. The biggest impact on your output quality is the printer quality setting.
To verify this on your system, create 3 identical files at 600, 300 and 150 dpi. Print each file at different print quality settings. Mark the settings on the back of each print to eliminate the psychological effect of knowing the parameters of each print. Have someone mix them up and then look at them, grade them in order of sharpness and quality. Only then, look at the back and see the image/print settings.
You can also use these samples to help when you have a customer who is demanding the highest quality setting. As stated in above posts, higher dpi files require longer RIP processing time. Actual print times are not effected by image DPI, only printer quality settings. The determining factor should be acceptable output at the final viewing distance.