I'll give my two cents worth......
I can't speak from experience for either question, but i DO know that with the DC4 you CAN take out the printed media, reload and plot. ColorControl (Summa's software) has a feauture built in where you can add reg. marks before printing to allow the user to laminate before plotting, etc. Not sure exact process of doing it as I have never needed it yet.
On the cutting part, that's pretty heavy but I don't know why it couldn't handle it, Summas are great machines. Again can't really speak from experience here, thickest vinyl I've ever cut on it was Oracal 651 (unlaminated!!)