Silicone works great for non-acrylic and non-polycarbonate applications. For those, Lexel is the best. It's the only adhesive I've found that specifically lists those items.
I posted this a while ago, but this is a picture of an acrylic panel that was adhered to concrete that had to be replaced.
On the flip side, I've removed acrylic signs from walls and could peel the silicone off like that gummy stuff they attach credit cards to paper with.
All of that being said, most sign companies still specify silicone in their drawings and some actually provide me with the tubes they prefer to use. Not my preference and typically smaller room ID signs will be fine with it. But if there's something exterior or with some weight to it, I'll use Lexel.