Cast or extruded? In my experience, use cast if you want clean edges. Extruded is good for tenant panels in monument signs, or channel letter faces that are getting trimcap.
Also, consider using multiple passes on materials thicker than, say, 1/4" to eliminate stressing the bits or the materials being cut.
As for spindle and feed rates, most of the players who make router bits have a chart that can come in handy.
Belin, and
Onsrud are common providers. For myself, I stuck with upcut bits and kept the RPMs at 24K. Depending on the material thickness and intricacy of what was being done, I could get as much as 200IPM for cutting speed.
EDIT:
henryz I'm impressed with cutting 1" in one pass. What size bit?