cutting fluid mist,
When the aluminum sticks to the cutter it will build up heat as well as become harder to move through the material. An oil or wax will help to keep the aluminum from sticking. You can also increase the chip size by slowing the speed of the cutter or increasing the feed speed.
The kind of material will also make a difference. 5051 is a soft aluminum. 2024 and 7075 are much harder. The softer the metal the more it will stick to the tool.
The width of the bit = the max depth of cut in aluminum. 1/4" bit = max 1/4" depth. With deep cuts orient your two mister nozzles so that a majority of the time they are blowing down into the tool path not just on the exposed bit.