If you plan on doing thousands of labels sub it out. While you may be able to get the roll stock how will you handle/keep it in register? Those rolls are most likely for dedicated presses and are 1000' up to 3000' long.
We looked into doing in house labels with our Roland and there is no way to make money. That is why we sub out. We use a contractor that can make a million labels a day off one press.
If you have enough repeat business that does volume you can invest in a dedicated label press. These will print, laminate, cut, strip and rewind unattended.