I have several customers that apply laminates to thier flatbed work, thinner laminates like AccuShield go on very nicely, and if you are using PS, give it a little heat and extra pressure to eliminate the halo of bubbles. With full bleed work, there is always a chance of the lam pulling the print off of the surface of the substrate, so I always tell people to leave a little margin around the print, so it will be encapsulated. I say laminate your heart away, it makes the colors pop, and provides abrasion resistance.