I do it all the time with a decent cutting mat, preferably self-healing and not a chewed up one, and a 48" aluminum straight edge clamped to at least one if not both edges of the table. Line the print right up to the straight edge and run the blade precisely along that edge while putting firm downward pressure on the straight edge to hold the material you're cutting in place. If I'm trimming something with a solid colored background, I use small crosshairs in the corners where the cuts go. I try to make the crosshairs just dark enough to see and align, but not dark enough to be noticeable on the finished product. I don't see the point in making twice the cuts and having no higher level of precision either way unless I'm missing something here. Once I have used the straight edge to make the long cuts, I then use a guillotine cutter to make the cross cuts, which is also very precise and takes very little effort to line up.