If you use VersaWorks it says to use RGB for raster and CMYK for Vector. The rip actually converts the image to the rgb to cmyk, so if you have it in cmyk, it converts it to rgb then back to cmyk, so you can have really messed up colors from the multiple conversions. That is what I was reading the manual anyways. So I do RGB for rasters and CMYK for vectors.
I'm astonished there is so much bizarre misinformation in this day and age; especially from a manual.
If your color management is setup conventionally, all incoming color gets converted from whatever the color is in the file to LAB then to CMYK for the media profile. So, to design in RGB, CMYK, or Pantone doesn't change if your print workflow converts or not - it always converts - and this should be a good thing.
Assuming your output profile does a decent to good job of giving you accurate output, RGB should give you a little bit better color than CMYK. The reality of it is the differences should be very small assuming you're comparing sRGB to US Web Coated SWOP CMYK.
There are times it is helpful to not convert in your RIP. Maybe you just want direct control over the CMYK numbers or to mix a leaner black. No matter the reasoning, you must have CMYK in your file in this case because there is no means to properly convert RGB with the conversion function turned off in the RIP. For most folks, this should be an unusual workflow and color conversions should be turned on most of the time if not all the time.