Yes..you need the hasp driver.
I'm running VE LXI Master 6.6v1 (same as Flexi) on windows 7 pro with virtual machine and xp.
I have a shortcut on my desktop to start the program.
When I click the program to start, I have to quickly right click on the program in the task bar,
click "manage usb attachments" and then click to "attach" the hasp driver and in my case
the usb-serial converter cable.
Works fine for me, and if you leave the program open all day, you only have to do it once when you first
start the program in the morning.
Hope this helps...